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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50330782
Substrate
n/a
Meas. Tech.
ChEMBL_685392 (CHEMBL1287592)
IC50
448±n/a nM
Citation
 Sako, Y; Ichikawa, S; Osada, A; Matsuda, A Synthesis and evaluation of 5-substituted 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as check point 1 kinase inhibitors. Bioorg Med Chem 18:7878-89 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50330782
Synonyms:
5-(3-Carbamoylbenzylaminocarbonyl)-1,3-dihydropyrrolo-[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL1278026
Type:
Small organic molecule
Emp. Form.:
C23H16N4O4
Mol. Mass.:
412.3975
SMILES:
NC(=O)c1cccc(CNC(=O)c2cc3C(=O)NC(=O)c3c3c4ccccc4[nH]c23)c1
Structure:
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