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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50331362
Substrate
n/a
Meas. Tech.
ChEMBL_687131 (CHEMBL1291708)
IC50
125±n/a nM
Citation
 Yan, X; Wang, Z; Sudom, A; Cardozo, M; DeGraffenreid, M; Di, Y; Fan, P; He, X; Jaen, JC; Labelle, M; Liu, J; Ma, J; McMinn, D; Miao, S; Sun, D; Tang, L; Tu, H; Ursu, S; Walker, N; Ye, Q; Powers, JP The synthesis and SAR of novel diarylsulfone 11ß-HSD1 inhibitors. Bioorg Med Chem Lett 20:7071-5 (2010) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50331362
Synonyms:
(R)-3'-cyclopropyl-4'-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)biphenyl-4-carbonitrile | CHEMBL1289407
Type:
Small organic molecule
Emp. Form.:
C25H20F3NO3S
Mol. Mass.:
471.491
SMILES:
C[C@@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1C1CC1)-c1ccc(cc1)C#N)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: