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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50331576
Substrate
n/a
Meas. Tech.
ChEMBL_687425 (CHEMBL1292101)
EC50
15000±n/a nM
Citation
 Zinzalla, G; Haque, MR; Basu, BP; Anderson, J; Kaye, SL; Haider, S; Hasan, F; Antonow, D; Essex, S; Rahman, KM; Palmer, J; Morgenstern, D; Wilderspin, AF; Neidle, S; Thurston, DE A novel small-molecule inhibitor of IL-6 signalling. Bioorg Med Chem Lett 20:7029-32 (2010) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50331576
Synonyms:
4-(pyrrolidin-1-ylsulfonyl)-N-(thiophen-2-ylmethyl)-5-p-tolylthiophene-2-carboxamide | CHEMBL1289974
Type:
Small organic molecule
Emp. Form.:
C21H22N2O3S3
Mol. Mass.:
446.606
SMILES:
Cc1ccc(cc1)-c1sc(cc1S(=O)(=O)N1CCCC1)C(=O)NCc1cccs1
Structure:
Search PDB for entries with ligand similarity: