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Target
Cathepsin L2
Ligand
BDBM50331769
Substrate
n/a
Meas. Tech.
ChEMBL_686702 (CHEMBL1290882)
IC50
28±n/a nM
Citation
 Beaulieu, C; Isabel, E; Fortier, A; Massé, F; Mellon, C; Méthot, N; Ndao, M; Nicoll-Griffith, D; Lee, D; Park, H; Black, WC Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease. Bioorg Med Chem Lett 20:7444-9 (2010) [PubMed]  Article 
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
  
Inhibitor
Name:
BDBM50331769
Synonyms:
(S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-3-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)butanamide | CHEMBL1288530
Type:
Small organic molecule
Emp. Form.:
C30H28F4N4O3S
Mol. Mass.:
600.627
SMILES:
CC(C)[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)N[C@@H](Cc1ccc(cc1F)C#N)C#N |r|
Structure:
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