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Target
Sphingosine kinase 1
Ligand
BDBM50331855
Substrate
n/a
Meas. Tech.
ChEMBL_686925 (CHEMBL1291294)
Ki
1330±n/a nM
Citation
 Hengst, JA; Wang, X; Sk, UH; Sharma, AK; Amin, S; Yun, JK Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg Med Chem Lett 20:7498-502 (2010) [PubMed]  Article 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM50331855
Synonyms:
CHEMBL1289102 | N'-(1-(3,4-dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
Type:
Small organic molecule
Emp. Form.:
C21H22N4O4
Mol. Mass.:
394.4238
SMILES:
COc1ccc(cc1)-c1cc([nH]n1)C(=O)NN=C(C)c1ccc(OC)c(OC)c1 |w:16.17|
Structure:
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