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Target
Neuropeptide S receptor
Ligand
BDBM50331943
Substrate
n/a
Meas. Tech.
ChEMBL_687364 (CHEMBL1292040)
IC50
10±n/a nM
Citation
 Micheli, F; Di Fabio, R; Giacometti, A; Roth, A; Moro, E; Merlo, G; Paio, A; Merlo-Pich, E; Tomelleri, S; Tonelli, F; Zarantonello, P; Zonzini, L; Capelli, AM Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: a new class of Neuropeptide S antagonists. Bioorg Med Chem Lett 20:7308-11 (2010) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14
Type:
PROTEIN
Mol. Mass.:
42692.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1276607
Residue:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50331943
Synonyms:
5-phenyl-2-(2-(piperidine-1-carbonyl)phenyl)-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-one | CHEMBL1290004
Type:
Small organic molecule
Emp. Form.:
C24H23N3O2
Mol. Mass.:
385.4583
SMILES:
O=C(N1CCCCC1)c1ccccc1N1Cn2c(ccc2-c2ccccc2)C1=O
Structure:
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