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Target
Oxytocin receptor
Ligand
BDBM50332720
Substrate
n/a
Meas. Tech.
ChEMBL_697993 (CHEMBL1633053)
EC50
2.6±n/a nM
Citation
 Muttenthaler, M; Andersson, A; de Araujo, AD; Dekan, Z; Lewis, RJ; Alewood, PF Modulating oxytocin activity and plasma stability by disulfide bond engineering. J Med Chem 53:8585-96 (2010) [PubMed]  Article 
Target
Name:
Oxytocin receptor
Synonyms:
OT-R | OXTR | OXYR_HUMAN | Oxytocin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42793.26
Organism:
Homo sapiens (Human)
Description:
Oxytocin OXTR HEK293::B2R9L7
Residue:
389
Sequence:
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA
  
Inhibitor
Name:
BDBM50332720
Synonyms:
(S)-1-((4R,7S,10S,13S,16S,19R)-4-amino-16-(2-amino-2-oxoethyl)-13-(3-amino-3-oxopropyl)-10-sec-butyl-7-(4-hydroxybenzyl)-5,8,11,14,17-pentaoxo-1-thia-2-selena-6,9,12,15,18-pentaazacycloicosane-19-carbonyl)-N-((S)-1-(2-amino-2-oxoethylamino)-3-methylbutyl)pyrrolidine-2-carboxamide | CHEMBL1630522
Type:
Small organic molecule
Emp. Form.:
C42H66N12O11SSe
Mol. Mass.:
1026.07
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se]SC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)NCC(N)=O |r|
Structure:
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