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Target
Cannabinoid receptor 1
Ligand
BDBM50332884
Substrate
n/a
Meas. Tech.
ChEMBL_694005 (CHEMBL1636581)
Ki
368.2±n/a nM
Citation
 Silvestri, R; Ligresti, A; La Regina, G; Piscitelli, F; Gatti, V; Lavecchia, A; Brizzi, A; Pasquini, S; Allarà, M; Fantini, N; Carai, MA; Bigogno, C; Rozio, MG; Sinisi, R; Novellino, E; Colombo, G; Di Marzo, V; Dondio, G; Corelli, F Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands. Eur J Med Chem 45:5878-86 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50332884
Synonyms:
1-(2,4-Difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-Nheptyl-4-methyl-1H-pyrazole-3-carboxamide | CHEMBL1631292
Type:
Small organic molecule
Emp. Form.:
C24H30F2N4O
Mol. Mass.:
428.518
SMILES:
CCCCCCCNC(=O)c1nn(c(c1C)-n1c(C)ccc1C)-c1ccc(F)cc1F |(21.32,-18.34,;20.51,-17.03,;18.97,-17.07,;18.17,-15.76,;16.63,-15.8,;15.82,-14.49,;14.28,-14.53,;13.47,-13.23,;11.93,-13.27,;11.13,-11.97,;11.18,-14.64,;11.6,-16.11,;10.33,-16.97,;9.13,-16,;9.67,-14.57,;8.84,-13.26,;7.71,-16.6,;6.42,-15.73,;6.33,-14.19,;5.23,-16.68,;5.74,-18.11,;7.28,-18.07,;7.9,-18.95,;10.32,-18.51,;8.99,-19.28,;8.99,-20.83,;10.33,-21.6,;10.33,-23.14,;11.66,-20.83,;11.66,-19.28,;13,-18.49,)|
Structure:
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