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Target
Cannabinoid receptor 1
Ligand
BDBM50332890
Substrate
n/a
Meas. Tech.
ChEMBL_694005 (CHEMBL1636581)
Ki
233.5±n/a nM
Citation
 Silvestri, R; Ligresti, A; La Regina, G; Piscitelli, F; Gatti, V; Lavecchia, A; Brizzi, A; Pasquini, S; Allarà, M; Fantini, N; Carai, MA; Bigogno, C; Rozio, MG; Sinisi, R; Novellino, E; Colombo, G; Di Marzo, V; Dondio, G; Corelli, F Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands. Eur J Med Chem 45:5878-86 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50332890
Synonyms:
1-(2,4-Dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-Nisopropyl-4-methyl-1H-pyrazole-3-carboxamide | CHEMBL1631296
Type:
Small organic molecule
Emp. Form.:
C20H22Cl2N4O
Mol. Mass.:
405.321
SMILES:
CC(C)NC(=O)c1nn(c(c1C)-n1c(C)ccc1C)-c1ccc(Cl)cc1Cl |(13.51,-5.25,;11.97,-5.24,;11.2,-6.57,;11.21,-3.91,;9.66,-3.9,;8.91,-2.58,;8.88,-5.25,;9.29,-6.72,;8.02,-7.57,;6.82,-6.61,;7.36,-5.18,;6.53,-3.87,;5.28,-6.53,;4.5,-5.2,;5.11,-3.78,;3.01,-5.53,;2.85,-7.04,;4.26,-7.67,;4.58,-9.18,;8.02,-9.12,;6.69,-9.89,;6.68,-11.44,;8.02,-12.21,;8.02,-13.75,;9.36,-11.44,;9.35,-9.89,;10.7,-9.1,)|
Structure:
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