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Target
Cannabinoid receptor 2
Ligand
BDBM50332893
Substrate
n/a
Meas. Tech.
ChEMBL_694006 (CHEMBL1636582)
Ki
133.5±n/a nM
Citation
 Silvestri, R; Ligresti, A; La Regina, G; Piscitelli, F; Gatti, V; Lavecchia, A; Brizzi, A; Pasquini, S; Allarà, M; Fantini, N; Carai, MA; Bigogno, C; Rozio, MG; Sinisi, R; Novellino, E; Colombo, G; Di Marzo, V; Dondio, G; Corelli, F Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands. Eur J Med Chem 45:5878-86 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50332893
Synonyms:
1-(2,4-Dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(3,3-dimethylbutyl)-4-methyl-1H-pyrazole-3-carboxamide | CHEMBL1631299
Type:
Small organic molecule
Emp. Form.:
C23H28Cl2N4O
Mol. Mass.:
447.401
SMILES:
Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)cc1Cl)C(=O)NCCC(C)(C)C |(14.88,-7.03,;14.36,-8.48,;12.9,-8.91,;12.84,-10.43,;14.29,-10.96,;14.71,-12.45,;15.24,-9.76,;16.78,-9.82,;17.32,-8.39,;16.49,-7.08,;18.84,-8.46,;19.26,-9.93,;17.98,-10.79,;17.98,-12.33,;16.65,-13.11,;16.65,-14.65,;17.98,-15.42,;17.98,-16.96,;19.32,-14.65,;19.31,-13.1,;20.66,-12.32,;19.67,-7.14,;18.95,-5.79,;21.21,-7.19,;21.93,-8.55,;23.47,-8.6,;24.2,-9.95,;23.39,-11.26,;25.74,-10,;24.74,-11.39,)|
Structure:
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