Reaction Details Report a problem with these data
Target
Thymidylate kinase
Ligand
BDBM50332930
Substrate
n/a
Meas. Tech.
ChEMBL_694285 (CHEMBL1637647)
Ki
420±n/a nM
Citation
 Familiar, O; Munier-Lehmann, H; Aínsa, JA; Camarasa, MJ; Pérez-Pérez, MJ Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone. Eur J Med Chem 45:5910-8 (2010) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50332930
Synonyms:
5-methyl-1-(4-(2-oxobenzo[cd]indol-1(2H)-yl)but-2-enyl)pyrimidine-2,4(1H,3H)-dione | CHEMBL1632625
Type:
Small organic molecule
Emp. Form.:
C20H17N3O3
Mol. Mass.:
347.3673
SMILES:
Cc1cn(C\C=C\CN2C(=O)c3cccc4cccc2c34)c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: