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Target
Thymidylate kinase
Ligand
BDBM50332934
Substrate
n/a
Meas. Tech.
ChEMBL_694285 (CHEMBL1637647)
Ki
7070±n/a nM
Citation
 Familiar, O; Munier-Lehmann, H; Aínsa, JA; Camarasa, MJ; Pérez-Pérez, MJ Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone. Eur J Med Chem 45:5910-8 (2010) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50332934
Synonyms:
1-(4-(5-amino-2-oxo-2,4,5,6-tetrahydro-1H-imidazo[4,5,1-ij]quinolin-1-yl)but-2-enyl)-5-methylpyrimidine-2,4(1H,3H)-dione | CHEMBL1631394
Type:
Small organic molecule
Emp. Form.:
C19H21N5O3
Mol. Mass.:
367.4017
SMILES:
Cc1cn(C\C=C\Cn2c3cccc4CC(N)Cn(c34)c2=O)c(=O)[nH]c1=O
Structure:
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