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Target
Thymidylate kinase
Ligand
BDBM50332938
Substrate
n/a
Meas. Tech.
ChEMBL_694285 (CHEMBL1637647)
Ki
300±n/a nM
Citation
 Familiar, O; Munier-Lehmann, H; Aínsa, JA; Camarasa, MJ; Pérez-Pérez, MJ Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone. Eur J Med Chem 45:5910-8 (2010) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk
Type:
PROTEIN
Mol. Mass.:
22636.29
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_208218
Residue:
214
Sequence:
MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
  
Inhibitor
Name:
BDBM50332938
Synonyms:
5-Bromo-1-[4-(2,2-dioxo-4,5-dihydro-3H-2lambda-6-thia-1,2a-diaza-acenaphthylen-1-yl)-but-2-enyl]-1H-pyrimidine-2,4-dione | CHEMBL1631399
Type:
Small organic molecule
Emp. Form.:
C17H17BrN4O4S
Mol. Mass.:
453.31
SMILES:
Brc1cn(C\C=C\CN2c3cccc4CCCN(c34)S2(=O)=O)c(=O)[nH]c1=O
Structure:
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