Reaction Details
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Nociceptin receptor
Ligand
BDBM50333106
Substrate
n/a
Meas. Tech.
ChEMBL_690183 (CHEMBL1634313)
EC50
355±n/a nM
Citation
Harrison, RS; Ruiz-Gómez, G; Hill, TA; Chow, SY; Shepherd, NE; Lohman, RJ; Abbenante, G; Hoang, HN Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice J Med Chem 53:8400-8408 (2010) [PubMed] Article More Info.:
Target
Name:
Nociceptin receptor
Synonyms:
K3 opiate receptor | KOR-3 | Kappa-type 3 opioid receptor | Nociceptin receptor | Nociceptin/Orphanin FQ, NOP receptor | OPRX_MOUSE | ORGC | Oor | Oprl | Oprl1 | Orphanin FQ receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40499.09
Organism:
MOUSE
Description:
Nociceptin/Orphanin FQ, NOP receptor 0 MOUSE::P35377
Residue:
367
Sequence:
MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
Inhibitor
Name:
BDBM50333106
Synonyms:
CHEMBL1631920 | H-FGGFTGK(Ac)RKSNRKK(Ac)ANQN-NH2
Type:
Small organic molecule
Emp. Form.:
C91H149N33O26
Mol. Mass.:
2121.3623
SMILES:
[#6]-[#6@@H](-[#8])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](-[#7])=O |r|
Structure:
