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Target
Methionine--tRNA ligase
Ligand
BDBM50333116
Substrate
n/a
Meas. Tech.
ChEMBL_693526 (CHEMBL1637421)
Ki
225±n/a nM
Citation
 Green, LS; Bullard, JM; Ribble, W; Dean, F; Ayers, DF; Ochsner, UA; Janjic, N; Jarvis, TC Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity. Antimicrob Agents Chemother 53:86-94 (2008) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase
Synonyms:
MetRS | Methionine--tRNA ligase | Methionyl-tRNA synthetase | SYM_HAEIN | metG
Type:
PROTEIN
Mol. Mass.:
77016.12
Organism:
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Description:
ChEMBL_693526
Residue:
682
Sequence:
MTTQPRKILVTCALPYANGAIHLGHMLEHIQADIWVRFQRMRGNKIHFVCADDAHGTPIMLNADKLGITPEELIAKAKADHIRDFAGFNISFDNYHSTHSEENKQLTAEIYNKLKANGFIKSKVISQLFDPEKNMFLPDRFVKGTCPKCKAEDQYGDNCEVCASTYSPMDLINPRSAVSGTTPIVKESEHFFFDLPAFEGMLKEWTRSGSLQSEIANKMQEWFESDLQQWDISRDAPYFGFEIPGAKDKFFYVWLDAPIGYMASFKNLCNREGIDFNEFWAEGSDAELYHFIGKDIVYFHSLFWPAMLEGSGYRKPTNVFAHGYVTVDGAKMSKSRGTFIQASTYLNHIDPECLRYYYAAKLNDRIEDLDFNLEDFVQRVNTDIVNKLVNLASRNAGFIAKRFEGKLADKLEDKSLFAEFTAQAEQIAAYYESREYNKTIREIMALTDKANKYIDEKAPWVIAKEEGKEAELQAVCSMGIELFRVLMSYLKPVLPKLAERAETFLQAELRWDNIHQPLLGHTLAPFKALFSRLEKKQIDAVVEETKALFAAANKAAEKTEAKPTALSAVEPIAETITIDDFAKLDMRVAKVLKCEAVPESNKLLRFELDLGDHTRQVFSGIKAAYNKPEELEGRFVIMVANLAPRKMKFGVSEGMILSAGTGGSDLFLLSADSGVTAGMQVK
  
Inhibitor
Name:
BDBM50333116
Synonyms:
2-(3-((4-bromo-5-(1-fluorovinyl)-3-methylthiophen-2-yl)methylamino)propylamino)quinolin-4(1H)-one | CHEMBL1631216
Type:
Small organic molecule
Emp. Form.:
C20H21BrFN3OS
Mol. Mass.:
450.368
SMILES:
Cc1c(Br)c(sc1CNCCCNc1cc(O)c2ccccc2n1)C(F)=C
Structure:
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