Reaction Details
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Inositol phosphorylceramide synthase catalytic subunit AUR1
Ligand
BDBM50333121
Substrate
n/a
Meas. Tech.
ChEMBL_690932 (CHEMBL1634540)
IC50
43±n/a nM
Citation
Aeed, PA; Young, CL; Nagiec, MM; Elhammer, AP Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob Agents Chemother 53:496-504 (2009) [PubMed] Article More Info.:
Target
Name:
Inositol phosphorylceramide synthase catalytic subunit AUR1
Synonyms:
Aureobasidin A resistance protein | IPC synthase catalytic subunit AUR1 | Phosphatidylinositol:ceramide phosphoinositol transferase | AUR1_YEAST | AUR1
Type:
PROTEIN
Mol. Mass.:
45190.29
Organism:
Baker's yeast
Description:
ChEMBL_690933
Residue:
401
Sequence:
MANPFSRWFLSERPPNCHVADLETSLDPHQTLLKVQKYKPALSDWVHYIFLGSIMLFVFITNPAPWIFKILFYCFLGTLFIIPATSQFFFNALPILTWVALYFTSSYFPDDRRPPITVKVLPAVETILYGDNLSDILATSTNSFLDILAWLPYGLFHFGAPFVVAAILFVFGPPTVLQGYAFAFGYMNLFGVIMQNVFPAAPPWYKILYGLQSANYDMHGSPGGLARIDKLLGINMYTTAFSNSSVIFGAFPSLHSGCATMEALFFCYCFPKLKPLFIAYVCWLWWSTMYLTHHYFVDLMAGSVLSYVIFQYTKYTHLPIVDTSLFCRWSYTSIEKYDISKSDPLAADSNDIESVPLSNLELDFDLNMTDEPSVSPSLFDGSTSVSRSSATSITSLGVKRA
Inhibitor
Name:
BDBM50333121
Synonyms:
Khafrefungin | CHEMBL1631582
Type:
Small organic molecule
Emp. Form.:
C33H56O9
Mol. Mass.:
n/a
SMILES:
CCCCCCCCCC[C@H](C)[C@@H](O)[C@@H](C)C=C(C)C=C(C)C(=O)[C@H](C)C=C(C)C(=O)O[C@H](CO)[C@@H](O)[C@H](O)C(O)=O |r,w:19.18,17.17,27.27|
Structure:
