Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50334732
Substrate
n/a
Meas. Tech.
ChEMBL_699283 (CHEMBL1647103)
Ki
410±n/a nM
Citation
 Liu, KG; Robichaud, AJ; Greenfield, AA; Lo, JR; Grosanu, C; Mattes, JF; Cai, Y; Zhang, GM; Zhang, JY; Kowal, DM; Smith, DL; Di, L; Kerns, EH; Schechter, LE; Comery, TA Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT(6) antagonists. Bioorg Med Chem 19:650-62 (2011) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50334732
Synonyms:
3-(3-Chlorophenylsulfonyl)-N-(piperidin-4-yl)-1H-indazol-5-amine HCl | CHEMBL1642882
Type:
Small organic molecule
Emp. Form.:
C18H19ClN4O2S
Mol. Mass.:
390.887
SMILES:
Clc1cccc(c1)S(=O)(=O)c1n[nH]c2ccc(NC3CCNCC3)cc12
Structure:
Search PDB for entries with ligand similarity: