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Target
Telomere resolvase ResT
Ligand
BDBM50335558
Substrate
n/a
Meas. Tech.
ChEMBL_713937 (CHEMBL1660353)
IC50
3160±n/a nM
Citation
 Lefas, G; Chaconas, G High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. Antimicrob Agents Chemother 53:4441-9 (2009) [PubMed]  Article 
Target
Name:
Telomere resolvase ResT
Synonyms:
REST_BORBU | resT
Type:
PROTEIN
Mol. Mass.:
54325.70
Organism:
Borrelia burgdorferi
Description:
ChEMBL_713937
Residue:
449
Sequence:
MPPKVKIKNDFEIFRKELEILYKKYLNNELSYLKLKEKLKILAENHKAILFRKDKFTNRSIILNLSKTRKIIKEYINLSVIERIRRDNTFLFFWKSRRIKELKNIGIKDRKKIEELIFSNQMNDEKSYFQYFIDLFVTPKWLNDYAHKYKIEKINSYRKEQIFVKINLNTYIEIIKLLLNQSRDIRLKFYGVLMAIGRRPVEVMKLSQFYIADKNHIRMEFIAKKRENNIVNEVVFPVFADPELIINSIKEIRYMEQTENLTKEIISSNLAYSYNRLFRQIFNNIFAPEESVYFCRAIYCKFSYLAFAPKNMEMNYWITKVLGHEPNDITTAFHYNRYVLDNLDDKADNSLLTLLNQRIYTYVRRKATYSTLTMDRLESLIKEHHIFDDNYIKTLIVIKNLMLKDNLETLAMVRGLNVKIRKAFKATYGYNYNYIKLTEYLSIIFNYKL
  
Inhibitor
Name:
BDBM50335558
Synonyms:
2-(4-(6-(6-carboxy-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-1H-benzo[d]imidazol-2-yl)phenyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6-carboxylic acid | CHEMBL1649740
Type:
Small organic molecule
Emp. Form.:
C39H20N4O8
Mol. Mass.:
672.5981
SMILES:
OC(=O)c1ccc2C(=O)N(C(=O)c3cccc1c23)c1ccc(cc1)-c1nc2ccc(cc2[nH]1)N1C(=O)c2cccc3c(ccc(C1=O)c23)C(O)=O
Structure:
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