Reaction Details Report a problem with these data
Target
Telomere resolvase ResT
Ligand
BDBM50096619
Substrate
n/a
Meas. Tech.
ChEMBL_713937 (CHEMBL1660353)
IC50
8670±n/a nM
Citation
 Lefas, G; Chaconas, G High-throughput screening identifies three inhibitor classes of the telomere resolvase from the lyme disease spirochete. Antimicrob Agents Chemother 53:4441-9 (2009) [PubMed]  Article 
Target
Name:
Telomere resolvase ResT
Synonyms:
REST_BORBU | resT
Type:
PROTEIN
Mol. Mass.:
54325.70
Organism:
Borrelia burgdorferi
Description:
ChEMBL_713937
Residue:
449
Sequence:
MPPKVKIKNDFEIFRKELEILYKKYLNNELSYLKLKEKLKILAENHKAILFRKDKFTNRSIILNLSKTRKIIKEYINLSVIERIRRDNTFLFFWKSRRIKELKNIGIKDRKKIEELIFSNQMNDEKSYFQYFIDLFVTPKWLNDYAHKYKIEKINSYRKEQIFVKINLNTYIEIIKLLLNQSRDIRLKFYGVLMAIGRRPVEVMKLSQFYIADKNHIRMEFIAKKRENNIVNEVVFPVFADPELIINSIKEIRYMEQTENLTKEIISSNLAYSYNRLFRQIFNNIFAPEESVYFCRAIYCKFSYLAFAPKNMEMNYWITKVLGHEPNDITTAFHYNRYVLDNLDDKADNSLLTLLNQRIYTYVRRKATYSTLTMDRLESLIKEHHIFDDNYIKTLIVIKNLMLKDNLETLAMVRGLNVKIRKAFKATYGYNYNYIKLTEYLSIIFNYKL
  
Inhibitor
Name:
BDBM50096619
Synonyms:
1,8,9-Trihydroxy-3-methoxy-benzo[4,5]furo[3,2-c]chromen-6-one | 7-methoxy-5,11,12-trihydroxy-coumestan | CHEMBL97453 | Wedelolactone
Type:
Small organic molecule
Emp. Form.:
C16H10O7
Mol. Mass.:
314.2464
SMILES:
COc1cc(O)c2c3oc4cc(O)c(O)cc4c3c(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: