Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM50335956
Substrate
n/a
Meas. Tech.
ChEMBL_716944 (CHEMBL1670972)
IC50
60±n/a nM
Citation
 Stock, N; Volkots, D; Stebbins, K; Broadhead, A; Stearns, B; Roppe, J; Parr, T; Baccei, C; Bain, G; Chapman, C; Correa, L; Darlington, J; King, C; Lee, C; Lorrain, DS; Prodanovich, P; Santini, A; Evans, JF; Hutchinson, JH; Prasit, P Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist. Bioorg Med Chem Lett 21:1036-40 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50335956
Synonyms:
2-(4'-acetamido-2'-(((benzyloxycarbonyl)(ethyl)amino)methyl)-6-methoxybiphenyl-3-yl)acetic acid | CHEMBL1668889
Type:
Small organic molecule
Emp. Form.:
C28H30N2O6
Mol. Mass.:
490.5476
SMILES:
CCN(Cc1cc(NC(C)=O)ccc1-c1cc(CC(O)=O)ccc1OC)C(=O)OCc1ccccc1
Structure:
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