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Target
Reverse transcriptase
Ligand
BDBM33411
Substrate
n/a
Meas. Tech.
ChEMBL_725038 (CHEMBL1678143)
IC50
250±n/a nM
Citation
 Chung, S; Wendeler, M; Rausch, JW; Beilhartz, G; Gotte, M; O'Keefe, BR; Bermingham, A; Beutler, JA; Liu, S; Zhuang, X; Le Grice, SF Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrob Agents Chemother 54:3913-21 (2010) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
64758.82
Organism:
Human immunodeficiency virus 2
Description:
ChEMBL_725038
Residue:
560
Sequence:
MAVAKVEPIKIMLKPGKDGPKLRQWPLTKEKIEALKEICEKMEKEGQLEEAPPTNPYNTPTFAIKKKDKNKWRMLIDFRELNKVTQDFTEIQLGIPHPAGLAKKRRITVLDVGDAYFSIPLHEDFRPYTAFTLPSVNNAEPGKRYIYKVLPQGWKGSPAIFQHTMRQVLEPFRKANKDVIIIQYMDDILIASDRTDLEHDRVILQLKELLNGLGFSTPDEKFQKDPPYHWMGYELWPTKWKLQKIQLPQKEIWTVNDIQKLVGVLNWAAQLYPGIKTKHLCRLIRGKMTLTEEVQWTELAEAELEENRIILSQEQEGHYYQEEKELEATVQKDQDNQWTYKIHQEDKILKVGKYAKVKNTHTNGIRLLAQVVQKIGKEALVIWGRIPKFHLPVEREIWEQWWDNYWQVTWIPDWDFVSTPPLVRLAFNLVGDPIPGAETFYTDGSCNRQSKEGKAGYVTDRGKDKVKKLEQTTNQQAELEAFAMALTDSGPKVNIIVDSQYVMGIVASQPTESESKIVNQIIEEMIKKEAIYVAWVPAHKGIGGNQEVDHLVSQGIRQVL
  
Inhibitor
Name:
BDBM33411
Synonyms:
β-Thujaplicinol | hydroxytropolone, 3
Type:
Small organic molecule
Emp. Form.:
C10H12O3
Mol. Mass.:
180.2005
SMILES:
CC(C)c1ccc(O)c(=O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: