Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM10870
Substrate
n/a
Meas. Tech.
ChEMBL_726067 (CHEMBL1678663)
pH
7.5±n/a
Ki
2±n/a nM
Comments
extracted
Citation
 Joseph, P; Ouahrani-Bettache, S; Montero, JL; Nishimori, I; Minakuchi, T; Vullo, D; Scozzafava, A; Winum, JY; Köhler, S; Supuran, CT A newß-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth. Bioorg Med Chem 19:1172-8 (2011) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM10870
Synonyms:
2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfonamide | Aminobenzolamide 12 | CHEMBL268439 | aminobenzolamide 17a | aminobenzolamide deriv. 43 | aromatic/heteroaromatic sulfonamide 15
Type:
Small organic molecule
Emp. Form.:
C8H9N5O4S3
Mol. Mass.:
335.383
SMILES:
Nc1ccc(cc1)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O
Structure:
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