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Target
Coagulation factor X
Ligand
BDBM50338335
Substrate
n/a
Meas. Tech.
ChEMBL_728148 (CHEMBL1687149)
IC50
12±n/a nM
Citation
 Mochizuki, A; Nagata, T; Kanno, H; Suzuki, M; Ohta, T 2-aminomethylphenylamine as a novel scaffold for factor Xa inhibitor. Bioorg Med Chem 19:1623-42 (2011) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50338335
Synonyms:
CHEMBL1682739 | N-[3-({[(5-Chlorothiophen-2-yl)carbonyl]amino}methyl)pyridin-4-yl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C19H18ClN5O2S2
Mol. Mass.:
447.962
SMILES:
CN1CCc2nc(sc2C1)C(=O)Nc1ccncc1CNC(=O)c1ccc(Cl)s1
Structure:
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