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Target
Beta-lactamase
Ligand
BDBM50339145
Substrate
n/a
Meas. Tech.
ChEMBL_733518 (CHEMBL1689856)
IC50
128±n/a nM
Citation
 Stachyra, T; Péchereau, MC; Bruneau, JM; Claudon, M; Frère, JM; Miossec, C; Coleman, K; Black, MT Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. Antimicrob Agents Chemother 54:5132-8 (2010) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_PSEAE | ampC | beta-Lactamase
Type:
Enzyme
Mol. Mass.:
43406.87
Organism:
Pseudomonas aeruginosa (PAO1)
Description:
P24735
Residue:
397
Sequence:
MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
  
Inhibitor
Name:
BDBM50339145
Synonyms:
CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octan-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C7H11N3O6S
Mol. Mass.:
265.244
SMILES:
NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O |r|
Structure:
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