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Target
Telomerase reverse transcriptase
Ligand
BDBM50339189
Substrate
n/a
Meas. Tech.
ChEMBL_736096 (CHEMBL1692770)
IC50
10000±n/a nM
Citation
 Casagrande, V; Salvati, E; Alvino, A; Bianco, A; Ciammaichella, A; D'Angelo, C; Ginnari-Satriani, L; Serrilli, AM; Iachettini, S; Leonetti, C; Neidle, S; Ortaggi, G; Porru, M; Rizzo, A; Franceschin, M; Biroccio, A N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. J Med Chem 54:1140-56 (2011) [PubMed]  Article 
Target
Name:
Telomerase reverse transcriptase
Synonyms:
EST2 | TCS1 | TERT | TERT_HUMAN | TRT
Type:
PROTEIN
Mol. Mass.:
127099.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1447029
Residue:
1132
Sequence:
MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
  
Inhibitor
Name:
BDBM50339189
Synonyms:
CHEMBL1689441 | N,N'-Bis[2-(1-piperidino)-ethyl]-1,7-[4-methyl-1-piperazinyl]-perylene-3,4,9,10-tetracarboxylic Diimide
Type:
Small organic molecule
Emp. Form.:
C48H56N8O4
Mol. Mass.:
809.0094
SMILES:
CN1CCN(CC1)c1cc2c3c(ccc4c5c(cc6c7c(ccc(c1c34)c57)c(=O)n(CCN1CCCCC1)c6=O)N1CCN(C)CC1)c(=O)n(CCN1CCCCC1)c2=O
Structure:
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