Reaction Details Report a problem with these data
Target
Placenta growth factor
Ligand
BDBM50339213
Substrate
n/a
Meas. Tech.
ChEMBL_736109 (CHEMBL1692892)
IC50
400±n/a nM
Citation
 Bower, KE; Lam, SN; Oates, BD; Del Rosario, JR; Corner, E; Osothprarop, TF; Kinhikar, AG; Hoye, JA; Preston, RR; Murphy, RE; Campbell, LA; Huang, H; Jimenez, J; Cao, X; Chen, G; Ainekulu, ZW; Datt, AB; Levin, NJ; Doppalapudi, VR; Pirie-Shepherd, SR; Bradshaw, C; Woodnutt, G; Lappe, RW Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery. J Med Chem 54:1256-65 (2011) [PubMed]  Article 
Target
Name:
Placenta growth factor
Synonyms:
PLGF_MOUSE | Pgf | Plgf
Type:
PROTEIN
Mol. Mass.:
17879.06
Organism:
Mus musculus
Description:
ChEMBL_736103
Residue:
158
Sequence:
MLVMKLFTCFLQVLAGLAVHSQGALSAGNNSTEVEVVPFNEVWGRSYCRPMEKLVYILDEYPDEVSHIFSPSCVLLSRCSGCCGDEGLHCVPIKTANITMQILKIPPNRDPHFYVEMTFSQDVLCECRPILETTKAERRKTKGKRKRSRNSQTEEPHP
  
Inhibitor
Name:
BDBM50339213
Synonyms:
CHEMBL1689478
Type:
Small organic molecule
Emp. Form.:
C90H130N26O21S2
Mol. Mass.:
1976.287
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C |r,wU:20.21,8.8,39.41,4.3,64.68,49.56,2.2,124.138,96.100,78.82,111.117,wD:56.60,79.85,85.89,115.126,35.79,30.113,(24.33,-18.35,;22.99,-19.12,;21.66,-18.36,;21.65,-16.82,;20.32,-19.14,;16.38,-21.41,;15.04,-20.63,;13.7,-21.38,;15.06,-19.1,;16.39,-18.34,;16.41,-16.8,;17.75,-16.06,;17.77,-14.52,;16.44,-13.74,;16.47,-12.19,;15.1,-14.49,;15.09,-16.03,;13.73,-18.3,;12.4,-19.06,;12.38,-20.6,;11.05,-18.27,;11.07,-16.73,;9.75,-15.94,;9.61,-14.42,;8.11,-14.08,;7.32,-15.4,;8.33,-16.56,;9.72,-19.05,;9.77,-20.53,;11.12,-21.27,;8.41,-21.3,;8.4,-22.85,;9.74,-23.65,;9.73,-25.22,;11.04,-26.05,;11.04,-27.59,;12.37,-28.37,;12.37,-29.91,;11.03,-30.67,;13.69,-30.67,;13.69,-32.23,;12.34,-32.99,;10.94,-32.36,;9.91,-33.51,;10.67,-34.84,;12.18,-34.53,;15.03,-29.92,;16.35,-30.69,;16.34,-32.23,;17.7,-29.93,;19.15,-30.41,;20.06,-29.17,;19.16,-27.92,;17.7,-28.39,;16.36,-27.64,;15.04,-28.4,;16.36,-26.1,;15.02,-25.33,;13.69,-26.11,;12.35,-25.35,;13.69,-27.65,;17.7,-25.31,;17.68,-23.78,;16.34,-23.02,;19.01,-23,;20.34,-23.77,;20.33,-25.31,;21.66,-26.09,;23,-25.32,;24.33,-26.1,;25.66,-25.33,;24.32,-27.63,;19.04,-21.44,;20.33,-20.69,;21.67,-21.45,;9.7,-28.36,;9.7,-29.89,;8.38,-27.59,;7.05,-28.36,;7.05,-29.9,;5.71,-30.67,;8.38,-30.66,;5.71,-27.58,;5.71,-26.04,;4.37,-28.36,;3.04,-27.58,;3.03,-26.04,;1.69,-25.27,;.37,-26.05,;-.96,-25.28,;-2.3,-26.05,;-3.63,-25.28,;-2.3,-27.59,;1.69,-28.36,;.36,-27.6,;1.7,-29.9,;.38,-30.67,;.38,-32.23,;-.96,-33.01,;-2.31,-32.24,;-3.66,-33.02,;-3.65,-34.58,;-5,-35.37,;-2.29,-35.35,;-.95,-34.57,;-.96,-29.9,;-2.3,-30.68,;-.96,-28.37,;7.09,-20.53,;5.74,-21.28,;5.74,-22.82,;4.4,-20.52,;3.05,-21.29,;1.74,-20.53,;1.73,-19,;.38,-21.31,;.4,-22.84,;-.92,-23.63,;-2.27,-22.88,;-3.58,-23.66,;-2.28,-21.34,;-.92,-20.54,;-.92,-19.01,;.42,-18.24,;-2.25,-18.23,;-2.24,-16.69,;-.9,-15.93,;.42,-16.71,;1.75,-15.94,;1.77,-14.4,;.43,-13.63,;-.9,-14.39,;-3.58,-18.99,;-4.93,-18.21,;-6.29,-18.99,;-4.93,-16.66,;4.39,-18.99,;3.05,-18.21,;5.72,-18.21,)|
Structure:
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