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Target
Falcipain-2
Ligand
BDBM50339249
Substrate
n/a
Meas. Tech.
ChEMBL_736241 (CHEMBL1693385)
IC50
42100±n/a nM
Citation
 Praveen Kumar, S; Gut, J; Guedes, RC; Rosenthal, PJ; Santos, MM; Moreira, R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem 46:927-33 (2011) [PubMed]  Article 
Target
Name:
Falcipain-2
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
55912.57
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50339249
Synonyms:
(Z/E)-(S)-2-((7-chloro-2-oxoindolin-3-ylidene)methylamino)-N-isopentyl-4-methylpentanamide | CHEMBL1689606
Type:
Small organic molecule
Emp. Form.:
C20H28ClN3O2
Mol. Mass.:
377.908
SMILES:
CC(C)CCNC(=O)[C@H](CC(C)C)N=CC1C(=O)Nc2c1cccc2Cl |r,w:14.14|
Structure:
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