Target
Falcipain-2
Ligand
BDBM50339262
Substrate
n/a
Meas. Tech.
ChEMBL_736241 (CHEMBL1693385)
IC50
>50000±n/a nM
Citation
 Praveen Kumar, SGut, JGuedes, RCRosenthal, PJSantos, MMMoreira, R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem 46:927-33 (2011) [PubMed]  Article 
Target
Name:
Falcipain-2
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
55912.57
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50339262
Synonyms:
(Z/E)-ethyl 2-((2-oxoindolin-3-ylidene)methylamino)acetate | CHEMBL1689594
Type:
Small organic molecule
Emp. Form.:
C13H14N2O3
Mol. Mass.:
246.2619
SMILES:
CCOC(=O)CN=CC1C(=O)Nc2ccccc12 |w:7.7|
Structure:
Search PDB for entries with ligand similarity: