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Target
Falcipain-2
Ligand
BDBM50339267
Substrate
n/a
Meas. Tech.
ChEMBL_736241 (CHEMBL1693385)
IC50
>50000±n/a nM
Citation
 Praveen Kumar, S; Gut, J; Guedes, RC; Rosenthal, PJ; Santos, MM; Moreira, R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem 46:927-33 (2011) [PubMed]  Article 
Target
Name:
Falcipain-2
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
55912.57
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50339267
Synonyms:
(Z/E)-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)indolin-2-one | CHEMBL1687962
Type:
Small organic molecule
Emp. Form.:
C21H19ClN4O
Mol. Mass.:
378.855
SMILES:
Clc1ccc2c(NCCCN=CC3C(=O)Nc4ccccc34)ccnc2c1 |w:11.11|
Structure:
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