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Target
Bombesin receptor subtype-3
Ligand
BDBM50340969
Substrate
n/a
Meas. Tech.
ChEMBL_740070 (CHEMBL1763130)
IC50
510±n/a nM
Citation
 Lo, MM; Chobanian, HR; Palyha, O; Kan, Y; Kelly, TM; Guan, XM; Reitman, ML; Dragovic, J; Lyons, KA; Nargund, RP; Lin, LS Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists. Bioorg Med Chem Lett 21:2040-3 (2011) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50340969
Synonyms:
(+/-)-4-((exo)-bicyclo[2.2.1]heptan-2-ylamino)-N-(isopropylcarbamoyl)pyridine-3-sulfonamide | CHEMBL1762245
Type:
Small organic molecule
Emp. Form.:
C16H24N4O3S
Mol. Mass.:
352.452
SMILES:
CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2 |r|
Structure:
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