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Target
Solute carrier family 15 member 1
Ligand
BDBM50341599
Substrate
n/a
Meas. Tech.
ChEMBL_744113 (CHEMBL1767474)
IC50
600000±n/a nM
Citation
 Flaten, GE; Kottra, G; Stensen, W; Isaksen, G; Karstad, R; Svendsen, JS; Daniel, H; Svenson, J In vitro characterization of human peptide transporter hPEPT1 interactions and passive permeation studies of short cationic antimicrobial peptides. J Med Chem 54:2422-32 (2011) [PubMed]  Article 
Target
Name:
Solute carrier family 15 member 1
Synonyms:
Intestinal H(+)/peptide cotransporter | Oligopeptide transporter small intestine isoform | Oligopeptide transporter, small intestine isoform | PEPT1 | Peptide transporter 1 | S15A1_HUMAN | SLC15A1
Type:
PROTEIN
Mol. Mass.:
78818.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1488839
Residue:
708
Sequence:
MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPVHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQPNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM
  
Inhibitor
Name:
BDBM50341599
Synonyms:
(S)-2-((S)-2-amino-3-(2,5,7-tri-tert-butyl-1H-indol-3-yl)propanamido)-5-guanidinopentanamide | (S)-2-[2-Amino-3-((S)-2,5,7-tri-tert-butyl-1H-indol-3-yl)-propionylamino]-5-guanidino-pentanoic acid amide | CHEMBL365705 | TbtR-NH2
Type:
Small organic molecule
Emp. Form.:
C29H49N7O2
Mol. Mass.:
527.7451
SMILES:
CC(C)(C)c1[nH]c2c(cc(cc2c1C[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(C)(C)C)C(C)(C)C |r|
Structure:
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