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Target
Adenosine receptor A3
Ligand
BDBM50341604
Substrate
n/a
Meas. Tech.
ChEMBL_742838 (CHEMBL1769841)
IC50
18±n/a nM
Citation
 Poli, D; Catarzi, D; Colotta, V; Varano, F; Filacchioni, G; Daniele, S; Trincavelli, L; Martini, C; Paoletta, S; Moro, S The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. J Med Chem 54:2102-13 (2011) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50341604
Synonyms:
1-(3-methoxyphenyl)-3-(4-oxo-3-phenyl-3,4-dihydrophthalazin-1-yl)urea | CHEMBL1766353
Type:
Small organic molecule
Emp. Form.:
C22H18N4O3
Mol. Mass.:
386.4033
SMILES:
COc1cccc(NC(=O)Nc2nn(-c3ccccc3)c(=O)c3ccccc23)c1
Structure:
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