Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM50341694
Substrate
n/a
Meas. Tech.
ChEMBL_743334 (CHEMBL1767581)
Ki
>100000±n/a nM
Citation
 Baragaña, B; McCarthy, O; Sánchez, P; Bosch-Navarrete, C; Kaiser, M; Brun, R; Whittingham, JL; Roberts, SM; Zhou, XX; Wilson, KS; Johansson, NG; González-Pacanowska, D; Gilbert, IH β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem 19:2378-91 (2011) [PubMed]  Article 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM50341694
Synonyms:
CHEMBL1766644 | rac-1-[2-(Carboxyethylamido)-4-trityloxybutyl]uracil
Type:
Small organic molecule
Emp. Form.:
C31H31N3O6
Mol. Mass.:
541.5943
SMILES:
OC(=O)CCNC(=O)C(CCOC(c1ccccc1)(c1ccccc1)c1ccccc1)Cn1ccc(=O)[nH]c1=O
Structure:
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