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Target
Matrix metalloproteinase-14
Ligand
BDBM50341820
Substrate
n/a
Meas. Tech.
ChEMBL_743597 (CHEMBL1768097)
IC50
8±n/a nM
Citation
Shiozaki, M; Maeda, K; Miura, T; Kotoku, M; Yamasaki, T; Matsuda, I; Aoki, K; Yasue, K; Imai, H; Ubukata, M; Suma, A; Yokota, M; Hotta, T; Tanaka, M; Hase, Y; Haas, J; Fryer, AM; Laird, ER; Littmann, NM; Andrews, SW; Josey, JA; Mimura, T; Shinozaki, Y; Yoshiuchi, H; Inaba, T Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors. J Med Chem 54:2839-63 (2011) [PubMed] Article
More Info.:
Target
Name:
Matrix metalloproteinase-14
Synonyms:
MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase
Type:
Protein
Mol. Mass.:
65900.19
Organism:
Homo sapiens (Human)
Description:
P50281
Residue:
582
Sequence:
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
Inhibitor
Name:
BDBM50341820
Synonyms:
(1S,2R,3R)-1-(6-Fluoro-4H-thieno[3,2-b]indole-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic Acid | CHEMBL1766904
Type:
Small organic molecule
Emp. Form.:
C21H17FN2O4S2
Mol. Mass.:
444.499
SMILES:
C[C@@H]1[C@H](c2ccccc2)[C@]1(NS(=O)(=O)c1cc2[nH]c3cc(F)ccc3c2s1)C(O)=O |r|