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Target
Isoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)
Ligand
BDBM50341831
Substrate
n/a
Meas. Tech.
ChEMBL_743614 (CHEMBL1768157)
Kd
3.7E4±n/a nM
Citation
 Herold, JM; Wigle, TJ; Norris, JL; Lam, R; Korboukh, VK; Gao, C; Ingerman, LA; Kireev, DB; Senisterra, G; Vedadi, M; Tripathy, A; Brown, PJ; Arrowsmith, CH; Jin, J; Janzen, WP; Frye, SV Small-molecule ligands of methyl-lysine binding proteins. J Med Chem 54:2504-11 (2011) [PubMed]  Article 
Target
Name:
Isoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)
Synonyms:
H-l(3)mbt | H-l(3)mbt protein | KIAA0681 | L(3)mbt protein homolog | L(3)mbt-like | L3MBT | L3MBTL | L3MBTL1 | LMBL1_HUMAN | Lethal(3)malignant brain tumor-like protein 1 | Lethal(3)malignant brain tumor-like protein 1 (4) | Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)
Type:
Protein
Mol. Mass.:
83871.06
Organism:
Homo sapiens (Human)
Description:
Q9Y468-4
Residue:
752
Sequence:
MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEMIDGEAFLLLTQADIVKIMSVKLGPALKIYNAILMFKNADDTLK
  
Inhibitor
Name:
BDBM50341831
Synonyms:
(S)-2-amino-3-(1H-imidazol-4-yl)-N-((S)-1-oxo-3-phenyl-1-(5-(pyrrolidin-1-yl)pentylamino)propan-2-yl)propanamide | CHEMBL1767021
Type:
Small organic molecule
Emp. Form.:
C24H36N6O2
Mol. Mass.:
440.5816
SMILES:
N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCCCN1CCCC1 |r|
Structure:
Search PDB for entries with ligand similarity: