Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM50341852
Substrate
n/a
Meas. Tech.
ChEMBL_743704 (CHEMBL1767518)
IC50
29400±n/a nM
Citation
 Botta, CB; Cabri, W; Cini, E; De Cesare, L; Fattorusso, C; Giannini, G; Persico, M; Petrella, A; Rondinelli, F; Rodriquez, M; Russo, A; Taddei, M Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation. J Med Chem 54:2165-82 (2011) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50341852
Synonyms:
3'-(8-(Hydroxyimino)-9-(methylamino)-9-oxononanamido)-[1,1'-biphenyl]-4-carboxylic Acid | CHEMBL1767037
Type:
Small organic molecule
Emp. Form.:
C23H27N3O5
Mol. Mass.:
425.4776
SMILES:
CNC(=O)C(CCCCCCC(=O)Nc1cccc(c1)-c1ccc(cc1)C(O)=O)N=O
Structure:
Search PDB for entries with ligand similarity: