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Target
Farnesyl diphosphate synthase
Ligand
BDBM50341917
Substrate
n/a
Meas. Tech.
ChEMBL_743413 (CHEMBL1767767)
IC50
490±n/a nM
Citation
 Rosso, VS; Szajnman, SH; Malayil, L; Galizzi, M; Moreno, SN; Docampo, R; Rodriguez, JB Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem 19:2211-7 (2011) [PubMed]  Article 
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
48827.21
Organism:
Trypanosoma cruzi
Description:
ChEMBL_939177
Residue:
425
Sequence:
MTAFACFPHSLFYSTRLPFFFFFFCVCVHCCLRYLCLLKCAYCCSDKNYFRPLNYFFYCLYLAMASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEKDPAKVAVVKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRKK
  
Inhibitor
Name:
BDBM50341917
Synonyms:
1-[(n-hex-1-ylamino)ethyl]-1,1-bisphosphonic acid | 2-(hexylamino)ethane-1,1-diyldiphosphonic acid | CHEMBL259192
Type:
Small organic molecule
Emp. Form.:
C8H21NO6P2
Mol. Mass.:
289.203
SMILES:
CCCCCCNCC(P(O)(O)=O)P(O)(O)=O
Structure:
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