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Target
Farnesyl diphosphate synthase
Ligand
BDBM50341912
Substrate
n/a
Meas. Tech.
ChEMBL_743414 (CHEMBL1767768)
IC50
68±n/a nM
Citation
 Rosso, VS; Szajnman, SH; Malayil, L; Galizzi, M; Moreno, SN; Docampo, R; Rodriguez, JB Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem 19:2211-7 (2011) [PubMed]  Article 
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
69493.18
Organism:
Toxoplasma gondii
Description:
ChEMBL_1282507
Residue:
646
Sequence:
MVDAVSLVSCRARHSHSLFAFSLSRRSCIQKHRFFSYVKSVPSSLPSPSSSSSPFTLSPRRRCLPPLVLPLEAAGHLPPALHSGSGISCPRSSSLSLSSSSPMRAPPSISLGLPPAQRPSLCFSPTSRLSAPVSPWSFSRQLSLATLAPLASVSSWKKAAALPKPDGAAAVSDERTSAERADALAGAWRASASHVEDRFKQAFPEVRGTLLSHIAGLDLPASLSARLLSYYARLLDYTCSGGKLTRGILVLYAAAAASHAPVLPPPSPSPAAAPASSASSVSSSPCSSSLAESERVPGSALSPALPPSSFRCLAALGWCVELLQSCFLVMDDVMDHSLTRRGKQCWYRCDGIGVSNAVNDSLVLEAAVYRVLREYLGDHPAYVQLQDLLLGNTFTTLIGQHLDSEDALAALSEASQNLESRQSEDNSSASSATAAGSSLLRDASLSDKDFTHHSYVSSSLSSSRSSPSLSASSLPSSEVLAQKLADRQATVARLKTSHYSFYLPTALGMTYGGLTDPALMAQAKELCLAIGEYFQVQDDYLDCFSDPKISGKIGSDIQEKKCCWLFVQAVRRASREDLAQLLRVYGQPEYVDWVKDLYRRLDLTSLYFQYEEETLAKLRRSVSSFPHDGMKAFFGLVLGRLHKRQK
  
Inhibitor
Name:
BDBM50341912
Synonyms:
1-[(n-Dec-1-ylamino)ethyl]1,1-bisphosphonic acid | CHEMBL1765147
Type:
Small organic molecule
Emp. Form.:
C12H29NO6P2
Mol. Mass.:
345.3093
SMILES:
CCCCCCCCCCNCC(P(O)(O)=O)P(O)(O)=O
Structure:
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