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Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50341979
Substrate
n/a
Meas. Tech.
ChEMBL_743570 (CHEMBL1768070)
IC50
360±n/a nM
Citation
 Vintonyak, VV; Waldmann, H; Rauh, D Using small molecules to target protein phosphatases. Bioorg Med Chem 19:2145-55 (2011) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50341979
Synonyms:
5-(Biphenyl-4-carbonyl)-1,3,4,5-tetrahydro-thiopyrano[4,3-b]indole-8-sulfonic acid | 5-(biphenylcarbonyl)-1,3,4,5-tetrahydrothiopyrano[4,3-b]indole-8-sulfonic acid | CHEMBL368885
Type:
Small organic molecule
Emp. Form.:
C24H19NO4S2
Mol. Mass.:
449.542
SMILES:
OS(=O)(=O)c1ccc2n(C(=O)c3ccc(cc3)-c3ccccc3)c3CCSCc3c2c1
Structure:
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