Reaction Details Report a problem with these data
Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50341980
Substrate
n/a
Meas. Tech.
ChEMBL_743570 (CHEMBL1768070)
IC50
430±n/a nM
Citation
 Vintonyak, VV; Waldmann, H; Rauh, D Using small molecules to target protein phosphatases. Bioorg Med Chem 19:2145-55 (2011) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50341980
Synonyms:
3-Benzyl-1-(biphenyl-4-carbonyl)-2-methyl-1H-indole-5-sulfonic acid | 3-benzyl-1-(biphenylcarbonyl)-2-methyl-1H-indole-5-sulfonic acid | CHEMBL178884
Type:
Small organic molecule
Emp. Form.:
C29H23NO4S
Mol. Mass.:
481.562
SMILES:
Cc1c(Cc2ccccc2)c2cc(ccc2n1C(=O)c1ccc(cc1)-c1ccccc1)S(O)(=O)=O
Structure:
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