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Target
M-phase inducer phosphatase 1
Ligand
BDBM50208827
Substrate
n/a
Meas. Tech.
ChEMBL_743506 (CHEMBL1767947)
IC50
22±n/a nM
Citation
 Vintonyak, VV; Waldmann, H; Rauh, D Using small molecules to target protein phosphatases. Bioorg Med Chem 19:2145-55 (2011) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50208827
Synonyms:
2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione | CHEMBL429095 | N1786 (NSC95397) | NSC 9539 | NSC 95397 | NSC-95397 | cid_262093
Type:
Small organic molecule
Emp. Form.:
C14H14O4S2
Mol. Mass.:
310.389
SMILES:
OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O |c:4|
Structure:
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