Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM16430
Substrate
n/a
Meas. Tech.
ChEMBL_744532 (CHEMBL1772553)
Ki
4900±n/a nM
Citation
 van Veldhoven, JPBlad, CCArtsen, CMKlopman, CWolfram, DRAbdelkadir, MJLane, JRBrussee, JIjzerman, AP Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A). Bioorg Med Chem Lett 21:2736-9 (2011) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM16430
Synonyms:
(2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cinnamic acid | Zimtsaeure | Zimtsaeure | trans-Cinnamate | t-Cinnamic acid | trans-Cinnamate
Type:
Small organic molecule
Emp. Form.:
C9H8O2
Mol. Mass.:
148.1586
SMILES:
OC(=O)\C=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: