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Target
6-phosphogluconate dehydrogenase, decarboxylating
Ligand
BDBM50148765
Substrate
n/a
Meas. Tech.
ChEMBL_744988 (CHEMBL1772003)
Ki
80±n/a nM
Citation
 Yep, A; Sorenson, RJ; Wilson, MR; Showalter, HD; Larsen, SD; Keller, PR; Woodard, RW Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis. Bioorg Med Chem Lett 21:2679-82 (2011) [PubMed]  Article 
Target
Name:
6-phosphogluconate dehydrogenase, decarboxylating
Synonyms:
6-phosphogluconate dehydrogenase, decarboxylating, putative
Type:
PROTEIN
Mol. Mass.:
52169.87
Organism:
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Description:
ChEMBL_744988
Residue:
479
Sequence:
MSMDVGVVGLGVMGANLALNIAEKGFKVAVFNRTYSKSEEFMKANASAPFAGNLKAFETMEAFAASLKKPRKALILVQAGAATDSTIEQLKKVFEKGDILVDTGNAHFKDQGRRAQQLEAAGLRFLGMGISGGEEGARKGPAFFPGGTLSVWEEIRPIVEAAAAKADDGRPCVTMNGSGGAGSCVKMYHNSGEYAILQIWGEVFDILRAMGLNNDEVAAVLEDWKSKNFLKSYMLDISIAAARAKDKDGSYLTEHVMDRIGSKGTGLWSAQEALEIGVPAPSLNMAVVSRQFTMYKTERQANASNAPGITQSPGYTLKNKSPSGPEIKQLYDSVCIAIISCYAQMFQCLREMDKVHNFGLNLPATIATFRAGCILQGYLLKPMTEAFEKNPNISNLMCAFQTEIRAGLQNYRDMVALITSKLEVSIPVLSASLNYVTAMFTPTLKYGQLVSLQRDVFGRHGYERVDKDGRESFQWPELQ
  
Inhibitor
Name:
BDBM50148765
Synonyms:
1-(hydroxyamino)-1-oxo-4-(phosphonooxy)butane-2,3-diyl diacetate | Acetic acid (1R,3R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxy-propyl ester | CHEMBL114269
Type:
Small organic molecule
Emp. Form.:
C8H14NO10P
Mol. Mass.:
315.1712
SMILES:
CC(=O)O[C@H](COP(O)(O)=O)[C@@H](OC(C)=O)C(=O)NO
Structure:
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