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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50342696
Substrate
n/a
Meas. Tech.
ChEMBL_745193 (CHEMBL1772424)
EC50
38±n/a nM
Citation
 Szewczyk, JW; Acton, J; Adams, AD; Chicchi, G; Freeman, S; Howard, AD; Huang, Y; Li, C; Meinke, PT; Mosely, R; Murphy, E; Samuel, R; Santini, C; Yang, M; Zhang, Y; Zhao, K; Wood, HB Design of potent and selective GPR119 agonists for type II diabetes. Bioorg Med Chem Lett 21:2665-9 (2011) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50342696
Synonyms:
(rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)cyclopropyl)methoxy)-N-cyclopropyl-2-fluorobenzamide | (rac)-trans-4-((2-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)cyclopropyl)methoxy)-N-cyclopropyl-2-fluorobenzamide | CHEMBL1771097
Type:
Small organic molecule
Emp. Form.:
C23H26ClFN4O2
Mol. Mass.:
444.93
SMILES:
Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Structure:
Search PDB for entries with ligand similarity: