Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50342731
Substrate
n/a
Meas. Tech.
ChEMBL_744205 (CHEMBL1771962)
Ki
21±n/a nM
Citation
 Griffith, DA; Hargrove, DM; Maurer, TS; Blum, CA; De Lombaert, S; Inthavongsay, JK; Klade, LE; Mack, CM; Rose, CR; Sanders, MJ; Carpino, PA Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett 21:2641-5 (2011) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50342731
Synonyms:
CHEMBL1771256 | N1-cyclopentyl-N2-(3-mesityl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)ethane-1,2-diamine
Type:
Small organic molecule
Emp. Form.:
C24H33N5
Mol. Mass.:
391.5523
SMILES:
Cc1nn2c(NCCNC3CCCC3)cc(C)nc2c1-c1c(C)cc(C)cc1C |(25.6,-3.01,;27.14,-3.01,;28.05,-1.76,;29.52,-2.24,;30.85,-1.48,;30.85,.06,;32.18,.84,;33.51,.07,;34.85,.84,;36.1,-.05,;36.11,-1.58,;37.58,-2.05,;38.47,-.79,;37.56,.45,;32.19,-2.24,;32.19,-3.79,;33.53,-4.56,;30.85,-4.56,;29.52,-3.79,;28.05,-4.27,;27.29,-5.61,;25.75,-5.61,;24.98,-4.29,;25,-6.95,;25.78,-8.28,;25.03,-9.62,;27.33,-8.26,;28.08,-6.92,;29.62,-6.9,)|
Structure:
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