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Target
Lysosomal alpha-glucosidase
Ligand
BDBM50342939
Substrate
n/a
Meas. Tech.
ChEMBL_744250 (CHEMBL1772057)
IC50
440±n/a nM
Citation
 Tanabe, G; Otani, T; Cong, W; Minematsu, T; Ninomiya, K; Yoshikawa, M; Muraoka, O Biological evaluation of 3'-O-alkylated analogs of salacinol, the role of hydrophobic alkyl group at 3' position in the side chain on thea-glucosidase inhibitory activity. Bioorg Med Chem Lett 21:3159-62 (2011) [PubMed]  Article 
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
Acidic alpha-glucosidase | Gaa | LYAG_RAT
Type:
PROTEIN
Mol. Mass.:
106191.24
Organism:
Rattus norvegicus
Description:
ChEMBL_1506157
Residue:
953
Sequence:
MNIRKPLCSNSVVGACTLVSLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQESYEPAPLHIQEHAEQLRAVPTQCDVTPNSRFDCAPDKGITQEQCEARGCCWVPAGQVLNGPVMGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLHFMIKDPTSKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLFFADQFLQLSTSLPSQHIAGLGEHLSPLMLSTEWTRITLWNRDVAPSQGVNLYGSHPFYLALEDGGLAHGVFLLNSNAMDVVLQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDGFADFPDMVHELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWIDMNEPSNFIRGSQQGCPDNELENPPYVPGVVGGALQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEHLAYSVPEILQFNLLGVPLVGADICGFQGNTTEELCVRWTQLGAFYPFMRNHNDLNSLPQEPYRFSETAQQAMRKAFTLRYALLPYLYTLFHGAHVKGDTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTDVTGYFPKGMWYNLQMVPVETLGSLPSSSPASSFRSIVHSKGQWLTLEAPLDTINVHLRAGYIIPLQGPSLTTTESRKQPMALAVALTESGEASGELFWDDGESLGVLERGAYTLVTFSAKNNTIVNKLVHVTKEGGELQLREVTILGVTTAPTQVLSNGISVSNFTYSPDDKSLSIPVSLLMGERFQIDWS
  
Inhibitor
Name:
BDBM50342939
Synonyms:
(1S,2R,3S,4S)-1-((2S,3S)-3-(benzyloxy)-2,4-dihydroxybutyl)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydro-1H-thiophenium tetrafluoroborate | CHEMBL1770628
Type:
Small organic molecule
Emp. Form.:
C16H25O6S
Mol. Mass.:
345.431
SMILES:
OC[C@H](OCc1ccccc1)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Structure:
Search PDB for entries with ligand similarity: