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Target
Adenosine receptor A3
Ligand
BDBM50086144
Substrate
n/a
Meas. Tech.
ChEMBL_744131 (CHEMBL1771830)
Ki
27.5±n/a nM
Citation
 Cheong, SL; Federico, S; Venkatesan, G; Paira, P; Shao, YM; Spalluto, G; Yap, CW; Pastorin, G Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorg Med Chem Lett 21:2898-905 (2011) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50086144
Synonyms:
4-(cyclopentylamino)-2-m-tolyl-[1,2,4]triazolo[4,3-a]quinoxalin-1(2H)-one | 4-Cyclopentylamino-2-m-tolyl-2H-[1,2,4]triazolo[4,3-a]quinoxalin-1-one | CHEMBL276321
Type:
Small organic molecule
Emp. Form.:
C21H21N5O
Mol. Mass.:
359.4243
SMILES:
Cc1cccc(c1)-n1nc2c(NC3CCCC3)nc3ccccc3n2c1=O
Structure:
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