Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50343255
Substrate
n/a
Meas. Tech.
ChEMBL_745571 (CHEMBL1775888)
Ki
>13000±n/a nM
Citation
 Lozama, A; Cunningham, CW; Caspers, MJ; Douglas, JT; Dersch, CM; Rothman, RB; Prisinzano, TE Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A. J Nat Prod 74:718-26 (2011) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50343255
Synonyms:
(2S,4aR,6aR,7R,9S,10aS,10bR)-Methyl 9-acetoxy-2-(8,8a,9,12,12a,13-hexahydro-8,13:9,12-diepoxy-5H-dibenzo[3,4:6,7]-cyclohept[1,2]naphthanen-5-on-10-yl)-6a,10b-dimethyl-4,10-dioxododecahydro-1H-benzo[f]isochromene-7-carboxylat | CHEMBL1773750
Type:
Small organic molecule
Emp. Form.:
C42H40O10
Mol. Mass.:
704.761
SMILES:
COC(=O)[C@@H]1C[C@H](OC(C)=O)C(=O)[C@H]2[C@@]1(C)CC[C@H]1C(=O)O[C@@H](C[C@]21C)C1=CC2OC1C1C3OC(C21)c1c3c2ccccc2c(=O)c2ccccc12 |r,t:29,TLB:22:26:29:31.35,30:31:33:37.36,34:35:27.26:29,51:36:31.35:33,THB:38:37:31.35:33|
Structure:
Search PDB for entries with ligand similarity: