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Target
Uracil-DNA glycosylase
Ligand
BDBM50343405
Substrate
n/a
Meas. Tech.
ChEMBL_747132 (CHEMBL1777498)
IC50
>200000±n/a nM
Citation
 Nuth, M; Huang, L; Saw, YL; Schormann, N; Chattopadhyay, D; Ricciardi, RP Identification of inhibitors that block vaccinia virus infection by targeting the DNA synthesis processivity factor D4. J Med Chem 54:3260-7 (2011) [PubMed]  Article 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
OPG116 | UDG | UNG | UNG_VACCW
Type:
PROTEIN
Mol. Mass.:
25071.48
Organism:
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR))
Description:
ChEMBL_747132
Residue:
218
Sequence:
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDYSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKAPINWAQGFIY
  
Inhibitor
Name:
BDBM50343405
Synonyms:
6-(9-chloro-4-(4-fluorophenyl)-5H-chromeno[4,3-b]pyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-ol | CHEMBL1774938
Type:
Small organic molecule
Emp. Form.:
C26H18ClFN2O3
Mol. Mass.:
460.884
SMILES:
OC1COc2ccc(cc2N1)-c1cc(-c2ccc(F)cc2)c2COc3ccc(Cl)cc3-c2n1
Structure:
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