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Target
Uracil-DNA glycosylase
Ligand
BDBM50343410
Substrate
n/a
Meas. Tech.
ChEMBL_747132 (CHEMBL1777498)
IC50
>200000±n/a nM
Citation
 Nuth, M; Huang, L; Saw, YL; Schormann, N; Chattopadhyay, D; Ricciardi, RP Identification of inhibitors that block vaccinia virus infection by targeting the DNA synthesis processivity factor D4. J Med Chem 54:3260-7 (2011) [PubMed]  Article 
Target
Name:
Uracil-DNA glycosylase
Synonyms:
OPG116 | UDG | UNG | UNG_VACCW
Type:
PROTEIN
Mol. Mass.:
25071.48
Organism:
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR))
Description:
ChEMBL_747132
Residue:
218
Sequence:
MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDYSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKAPINWAQGFIY
  
Inhibitor
Name:
BDBM50343410
Synonyms:
7-(4-chlorobenzyl)-8-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)-3-methyl-1H-purine-2,6(3H,7H)-dione | CHEMBL1444687
Type:
Small organic molecule
Emp. Form.:
C25H27ClN6O3
Mol. Mass.:
494.973
SMILES:
COc1ccc(cc1)N1CCN(Cc2nc3n(C)c(=O)[nH]c(=O)c3n2Cc2ccc(Cl)cc2)CC1
Structure:
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